Low External K+ Regulates Na,K-ATPase and ßa Gene Expression in Rat Cardiac Myocytes

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Population

Primary cultures of neonatal rat cardiac myocytes

Comparison

Incubation in medium containing low K+ for 72 h vs Control cells exposed to 5.4 mmol/L K+

Design

Preclinical

Follow-up

72 hours

Authors

Discussion

Low K+ effects on rat myocyte Na,K-ATPase require human validation; leaves open arrhythmia implications in hypokalemia.

Population

Primary cultures of neonatal rat cardiac myocytes

Intervention

Incubation in medium containing low K+ (0.3 mmol/L K+) for 72 h

Comparator

Control cells exposed to 5.4 mmol/L K+

Outcome

Abundance of Na,K-ATPase alpha 1 and beta 1 mRNAssurrogate

Low external potassium upregulates Na,K-ATPase alpha 1 and beta 1 gene expression in neonatal rat cardiac myocytes.

Qin et al. (1994) studied this question.

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