March 1, 1999EndocrinologyOpen Access

Regulation of Natriuretic Peptide Receptors by Thyrotropin in FRTL-5 Rat Thyroid Cells: Evidence for Nonguanylate Cyclase Atrial Natriuretic Factor-Binding Sites in Cells Lacking the Natriuretic Peptide Receptor C

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Population

FRTL-5 rat thyroid cells and FRTL cells

Comparison

TSH treatment, forskolin, and2cAMP vs TSH-deficient (5H) cultures

Design

Preclinical

Authors

DSDonald F. SellittiUniformed Services University of the Health Sciences SDSonia Q. DoiSmithsonian Institution

Discussion

Member takes

Implication

TSH may upregulate non-cGMP-coupled ANF sites in rat thyroid cells; leaves open their identity, function, and human relevance.

Structured PICO

Population

FRTL-5 rat thyroid cells and FRTL cells

Intervention

TSH treatment (1 mIU/ml bovine TSH, 6H medium), forskolin, and (Bu)2cAMP

Comparator

TSH-deficient (5H) cultures

Outcome

ANF-induced and CNP-induced intracellular cGMP formation, and natriuretic peptide receptor binding and transcript levelssurrogate

In FRTL-5 rat thyroid cells, TSH upregulates ANF-binding sites that are not coupled to cGMP production and are independent of NPR-A, NPR-B, and NPR-C.

Cite This Study

Sellitti et al. (1999) studied this question.

synapsesocial.com/papers/6a8916e46abbd4965f28b247 https://doi.org/10.1210/endo.140.3.6591

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Regulation of Natriuretic Peptide Receptors by Thyrotropin in FRTL-5 Rat Thyroid Cells: Evidence for Nonguanylate Cyclase Atrial Natriuretic Factor-Binding Sites in Cells Lacking the Natriuretic Peptide Receptor C

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Regulation of Natriuretic Peptide Receptors by Thyrotropin in FRTL-5 Rat Thyroid Cells: Evidence for Nonguanylate Cyclase Atrial Natriuretic Factor-Binding Sites in Cells Lacking the Natriuretic Peptide Receptor C

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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