Characterization by Affinity Cross-Linking of a Receptor for Atrial Natriuretic Peptide in Cultured Human Thyroid Cells Associated with Reductions in Both Adenosine 3′5′-Monophosphate Production and Thyroglobulin Secretion*

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Population

Cultured human thyroid cells and a bovine endothelial cell line

Design

Preclinical

Authors

Discussion

May modulate thyroglobulin release in vitro; hypothesis-generating for ANP-thyroid interactions and requires in vivo confirmation.

Population

Cultured human thyroid cells and a bovine endothelial cell line

Intervention

Atriopeptin (ANP) at concentrations ranging from 0.01 to 10 nmol/L

Outcome

Characterization of the ANP receptor by affinity cross-linking and measurement of thyroglobulin (Tg), cGMP, and cAMP concentrationssurrogate

In cultured human thyroid cells, ANP reduces thyroglobulin release likely via an inhibitory cAMP pathway mediated by a specific 70-kD ANP receptor.

Tseng et al. (1990) studied this question.

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