Chimeric hepatitis B virus core particles as probes for studying peptide-integrin interactions
Population
Escherichia coli, guinea pigs, cultured eukaryotic cells, and purified integrins
Comparison
Chimeric hepatitis B virus core particles… vs Mutant particles carrying RGE sequence…
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Hypothesis-generating for HBc chimeras in integrin studies; leaves open translation to human vaccines.
Structured PICO
P
Population
Escherichia coli, guinea pigs, cultured eukaryotic cells, and purified integrins
I
Intervention
Chimeric hepatitis B virus core (HBc) particles containing an RGD-containing epitope from the foot-and-mouth disease virus (FMDV) VP1 protein
C
Comparator
Mutant particles carrying RGE sequence, competitive peptide GRGDS, and FMDV
O
Outcome
Binding to cultured eukaryotic cells and purified integrins, and elicitation of antibodiessurrogate
Chimeric HBc particles can serve as a simple system for exploring interactions of specific peptide sequences with cellular receptors like integrins.
Cite This Study
Chambers et al. (1996) studied this question.