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February 1, 1987Molecular and Cellular Biology

Different Functional Domains of the Adenovirus E1A Gene are Involved in Regulation of Host Cell Cycle Products

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Population

Quiescent primary BRK (baby rat kidney) cells

Design

Preclinical

Authors

BZBrad ZerlerDoctors Company (United States)RRRichard J. RobertsNew England Biolabs (United States)MMMichael B. MathewsRutgers, The State University of New Jersey

Discussion

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Implication

Findings in primary rodent cells warrant clinical caution; extends mapping of E1A domains for cell-cycle control.

Structured PICO

P
Population
Quiescent primary BRK (baby rat kidney) cells
I
Intervention
Different domains of the adenovirus E1A proteins (deletion mutants)
O
Outcome
Cell cycle effects including induction of synthesis of proliferating cell nuclear antigen, stimulation of DNA synthesis, induction of mitosis, stimulation of proliferation, and activation of cellular thymidylate synthase genesurrogate

Different functional domains of the adenovirus E1A proteins independently regulate distinct host cell cycle products and processes in primary BRK cells.

Cite This Study

Zerler et al. (1987) studied this question.

synapsesocial.com/papers/6a891fe59f05dd9930a2bbf0https://doi.org/10.1128/mcb.7.2.821-829.1987
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Transformation properties of type 5 adenovirus mutants that differentially express the E1A gene products.1984 · 149 citations
  2. 2A Novel General Approach to Eucaryotic Mutagenesis Functionally Identifies Conserved Regions within the Adenovirus 13S E1A Polypeptide1986 · 12 citations
  3. 3Autoantibody to a Nuclear Antigen in Proliferating Cells1978 · 886 citations