February 1, 1987Molecular and Cellular Biology

Different Functional Domains of the Adenovirus E1A Gene are Involved in Regulation of Host Cell Cycle Products

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Population

Quiescent primary BRK (baby rat kidney) cells

Design

Preclinical

Authors

BZBrad ZerlerDoctors Company (United States)RRRichard J. RobertsNew England Biolabs (United States)MMMichael B. MathewsRutgers, The State University of New Jersey

Discussion

Member takes

Implication

Findings in primary rodent cells warrant clinical caution; extends mapping of E1A domains for cell-cycle control.

Structured PICO

Population

Quiescent primary BRK (baby rat kidney) cells

Intervention

Different domains of the adenovirus E1A proteins (deletion mutants)

Outcome

Cell cycle effects including induction of synthesis of proliferating cell nuclear antigen, stimulation of DNA synthesis, induction of mitosis, stimulation of proliferation, and activation of cellular thymidylate synthase genesurrogate

Different functional domains of the adenovirus E1A proteins independently regulate distinct host cell cycle products and processes in primary BRK cells.

Cite This Study

Zerler et al. (1987) studied this question.

synapsesocial.com/papers/6a891fe59f05dd9930a2bbf0 https://doi.org/10.1128/mcb.7.2.821-829.1987

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Different Functional Domains of the Adenovirus E1A Gene are Involved in Regulation of Host Cell Cycle Products

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Different Functional Domains of the Adenovirus E1A Gene are Involved in Regulation of Host Cell Cycle Products

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider