Disparities in the interaction of rat and human lipoproteins with cultured rat fibroblasts and smooth muscle cells. Requirements for homology for receptor binding activity.
Population
Cultured rat fibroblasts, rat smooth muscle cells, and human fibroblasts
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
Metabolic studies using human lipoproteins in rats require cautious interpretation; leaves open validity of cross-species receptor data.
Structured PICO
P
Population
Cultured rat fibroblasts, rat smooth muscle cells, and human fibroblasts
I
Intervention
Rat and human lipoproteins (VLDL, chylomicron remnants, LDL, HDL1)
O
Outcome
Lipoprotein receptor binding activity, internalization, and degradationsurrogate
Due to the inability of human LDL to interact with rat fibroblast receptors, metabolic studies using human lipoproteins in rats must be interpreted cautiously.
Cite This Study
Innerarity et al. (1980) studied this question.