Why the study?
Does adrenalectomy prevent angiotensin II-induced activation of cardiac gene expression in rats?
Population
Sham-operated and adrenalectomized rats
Comparison
Angiotensin II infusion (33 microg/kg x h, sc) vs Sham-operated rats vs adrenalectomized rats
Design
Preclinical
Follow-up
up to 72 hours
Authors
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Adrenal factors may mediate early cardiac gene responses to Ang II in rats; leaves open relevance to human hypertension or HF.
Does adrenalectomy prevent angiotensin II-induced activation of cardiac gene expression in rats?
Factors derived from the adrenal glands are required for the early activation of cardiac gene expression in response to angiotensin II-induced hypertension.
Földes et al. (2001) studied this question.
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