Population
Spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY) aged 4-64 weeks
Comparison
Spontaneous hypertension (disease model) vs Normotensive Wistar-Kyoto rats (WKY)
Design
Preclinical
Follow-up
Up to 64 weeks of age
Authors
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Hypertension may promote polyneuropathy; leaves open translation to human disease and clinical practice.
Sustained severe hypertension in a rat model causes slowed nerve conduction velocity and pathological abnormalities of hindlimb nerves, supporting hypertension as a risk factor for polyneuropathy.
Nukada et al. (2016) studied this question.
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