Why the study?
Does intracerebroventricular injection of AT1-specific antibody inhibit dipsogenic and blood pressure responses induced by centrally injected angiotensin II?
Does intracerebroventricular injection of AT1-specific antibody inhibit dipsogenic and blood pressure responses induced by centrally injected angiotensin II?
The study demonstrates that AT1 receptor antibodies can inhibit the central physiological responses (dipsogenic and blood pressure) mediated by angiotensin II in the brain.
Answers are grounded in this paper and cite their sources.
Central AT1 antibody effects remain preclinical; leaves open translation to human hypertension therapy.
Angiotensin type-1 receptor subtypes (AT1) are implicated in the physiological actions of angiotensin II in the brain. In the present study we used an AT1 receptor antibody and a polymerase chain reaction--synthesized AT1 receptor complementary DNA to show that the hypothalamus expresses significantly higher levels of AT1 receptor messenger RNA and protein compared with the brain stem. Intracerebroventricular injections of AT1-specific antibody blocks the dipsogenic and blood pressure responses induced by centrally injected angiotensin II. These results demonstrate the expression of AT1 receptor gene in the brain and that the AT1 receptor antibody is able to inhibit the physiological responses of angiotensin II mediated by the brain.
No takes yet. Share an insight, caveat, or question.
Richards et al. (1993) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: