Why the study?
Does oral cortisol impair cholinergic vasodilatation in healthy normotensive men?
Population
14 healthy normotensive men
Comparison
Oral cortisol for 2 or 5 days vs Placebo
Design
RCT, randomized, double-blind
Follow-up
5 days
Authors
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Cortisol impairs cholinergic vasodilatation in healthy men; supports endothelial NO involvement in glucocorticoid hypertension.
Does oral cortisol impair cholinergic vasodilatation in healthy normotensive men?
Exogenous cortisol impairs cholinergic vasodilatation in healthy men, suggesting glucocorticoid-induced hypertension may involve endothelial nitric oxide system abnormalities.
Mangos et al. (2000) studied this question.
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