Why the study?
Does NASBA-beacon improve or simplify the detection of enterovirus RNA compared to NASBA-ECL in clinical specimens?
Population
133 cerebrospinal fluid and 27 stool samples for detection of enteroviruses
Comparison
Real-time nucleic acid sequence-based… vs Standard NASBA with postamplification…
Design
Other
Authors
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Supports NASBA-beacon evaluation for EV detection; leaves open routine replacement of NASBA-ECL pending validation.
Does NASBA-beacon improve or simplify the detection of enterovirus RNA compared to NASBA-ECL in clinical specimens?
Real-time NASBA-beacon is a faster and simpler alternative to NASBA-ECL for detecting enterovirus RNA, despite slightly lower sensitivity and higher reagent costs.
Landry et al. (2005) studied this question.
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