What question did this study set out to answer?

To evaluate the acute implantation characteristics and chronic pacing and sensing thresholds of steroid-eluting unipolar ventricular electrodes.

November 1, 1988Pacing and Clinical Electrophysiology

Clinical Experience with Steroid‐Eluting Unipolar Electrodes

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Why the study?

Do steroid-eluting unipolar electrodes maintain low pacing thresholds in patients requiring ventricular pacing?

Population

23 patients (17 females, 6 males) requiring ventricular pacing

Design

Case_series

Follow-up

1 to 88 weeks (mean 23.22 +/- 4.35 weeks)

Authors

FPFarouk A. PirzadaBoston University LMLawrence J. MoschittoBoston University DDDEBORAH DIORIOBoston University

Discussion

Member takes

Implication

May support steroid-eluting electrodes for low thresholds in ventricular pacing; hypothesis-generating and should not change practice.

Key Points

To evaluate the acute implantation characteristics and chronic pacing and sensing thresholds of steroid-eluting unipolar ventricular electrodes.
Monitored 23 patients (17 females, 6 males) implanted with Medtronic 4003 (n=21) or 5023 (n=2) steroid-eluting ventricular leads paired with various pulse generators in VVIM (n=13) or DDD (n=10) modes.
Measured pacing thresholds, lead impedance, and R-wave sensing at implantation (0.50 msec pulse width) and during follow-up visits ranging from 1 to 88 weeks (mean 23.22 ± 4.35 weeks).
At implant, the mean pacing threshold was 0.40 ± 0.02 V at 0.66 ± 0.05 mA (0.50 msec pulse width), with lead resistance of 565.43 ± 22.07 ohms and R-wave amplitude of 9.24 ± 1.06 mV.
Chronic follow-up demonstrated pulse width thresholds at 2.5 V of 0.10 msec in 11 patients and ≤0.05 msec in 12 patients; at 5.0 V, 22 of 23 patients had no loss of capture at 0.05 msec.
During the initial 24 weeks, pulse width thresholds were <0.20 msec at 2.5 V (n=15) and <0.70 msec at 0.8 V (n=6), with no loss of sensing detected on standard electrocardiographic evaluations.

Structured PICO

Do steroid-eluting unipolar electrodes maintain low pacing thresholds in patients requiring ventricular pacing?

Population

23 patients (17 females, 6 males) requiring ventricular pacing

Intervention

Steroid-eluting unipolar electrodes (Medtronic 4003 [n=21] or 5023 [n=2]) implanted in the ventricular chamber

Outcome

Pacing thresholds (acute at implantation and chronic during follow-up)surrogate

Steroid-eluting unipolar electrodes maintain very low pacing thresholds in both the early and chronic follow-up phases without loss of sensing.

Cite This Study

Pirzada et al. (1988) studied this question.

synapsesocial.com/papers/6a89427de2cdaa7909621668 https://doi.org/10.1111/j.1540-8159.1988.tb06304.x

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Clinical Experience with Steroid‐Eluting Unipolar Electrodes

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Clinical Experience with Steroid‐Eluting Unipolar Electrodes

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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