Cytomegalovirus Infection With Interleukin-6 Response Predicts Cardiac Mortality in Patients With Coronary Artery Disease
Why the study?
Does previous CMV infection predict cardiac mortality in patients with coronary artery disease and an inflammatory response?
Population
989 patients with documented coronary artery disease who underwent coronary angiography
Comparison
Cytomegalovirus seropositivity with elevated… vs CMV seronegativity or lack of IL-6 elevation
Design
Cohort
Follow-up
median 3.1 years (maximum 4.3 years)
Authors
Discussion
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Member takes
Implication
May flag higher cardiac mortality risk in CAD with elevated IL-6; hypothesis-generating for CMV-inflammation link, needs prospective confirmation.
Structured PICO
Does previous CMV infection predict cardiac mortality in patients with coronary artery disease and an inflammatory response?
P
Population
989 patients with documented coronary artery disease who underwent coronary angiography
I
Intervention
Cytomegalovirus (CMV) seropositivity with elevated interleukin-6 (IL-6) levels (≥11.9 pg/mL)
C
Comparator
CMV seronegativity or lack of IL-6 elevation
O
Outcome
Future cardiac disease-related deathhard clinical
CMV seropositivity predicts future cardiac mortality in patients with coronary artery disease only when accompanied by an inflammatory response, supporting the hypothesis that CMV's atherosclerotic effects are mediated through inflammation.
Cite This Study
Blankenberg et al. (2001) studied this question.