What does this research mean for the field?

In assisted reproductive technology cycles, anti-Müllerian hormone (AMH) levels are positively associated with oocyte yield but negatively associated with fertilization and clinical pregnancy outcomes, indicating it reflects ovarian reserve quantity rather than optimal reproductive potential. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To investigate the dual effects of anti-Müllerian hormone (AMH) on ovarian response, fertilization outcomes, and clinical pregnancy rates in assisted reproductive technology cycles.

August 22, 2026Obstetrics & Gynecology ScienceOpen Access

Dual effects of anti-Müllerian hormone on ovarian response and fertilization in assisted reproductive technology cycles: a retrospective cohort study

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Authors

HPHyo-Jin ParkDaegu University JJJae-Hong JooKorea University Medical Center YKYun Hee KooMaria Fertility Hospital

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Implication

Cohort study reveals elevated anti-Müllerian hormone increases oocyte yield but reduces fertilization in ART cycles, suggesting high hormone levels reflect egg quantity over reproductive quality.

Key Points

To investigate the dual effects of anti-Müllerian hormone (AMH) on ovarian response, fertilization outcomes, and clinical pregnancy rates in assisted reproductive technology cycles.
Analyzed 4,399 IVF or ICSI cycles from 2018 to 2023 after screening 6,312 cycles and excluding non-ART cycles, missing data, and extreme BMI values (<18 or ≥45 kg/m²).
Applied multivariable linear regression to evaluate retrieved oocytes and normally fertilized embryos (two pronuclei), and multivariable logistic regression to assess clinical pregnancy.
AMH was strongly positively associated with retrieved oocyte count (β = 2.348; P < 0.001) but showed a significant negative association with fertilized embryo count after adjusting for age, BMI, fertilization method, and retrieved oocytes (β = -0.044; P = 0.027).
Cycles with AMH ≥10 ng/mL demonstrated higher oocyte yield but significantly lower fertilization rates (0.561 vs. 0.694; P < 0.001) and lower clinical pregnancy rates (5.7% vs. 23.1%; P < 0.001) compared to cycles with AMH <10 ng/mL.
Increasing age and elevated AMH levels were independently associated with reduced odds of achieving a clinical pregnancy.

Cite This Study

Park et al. (2026) studied this question.

synapsesocial.com/papers/6a895eeeca7ade938187d25f https://doi.org/10.5468/ogs.26089

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Implication

Cohort study reveals elevated anti-Müllerian hormone increases oocyte yield but reduces fertilization in ART cycles, suggesting high hormone levels reflect egg quantity over reproductive quality.

Dual effects of anti-Müllerian hormone on ovarian response and fertilization in assisted reproductive technology cycles: a retrospective cohort study

Discussion

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Implication

Key Points

Cite This Study

Dual effects of anti-Müllerian hormone on ovarian response and fertilization in assisted reproductive technology cycles: a retrospective cohort study

Discussion

Member takes

Implication

Key Points

Cite This Study

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