Methodological study demonstrates mild on-DNA radical iodosulfonylation of alkynes at room temperature, indicating broader chemical space for DNA-encoded libraries.
The first mild, on-DNA radical iodosulfonylation of alkynes enables the synthesis of β-iodovinyl sulfones at room temperature while maintaining DNA integrity. This method provides structurally diverse bifunctional intermediates, facilitating late-stage orthogonal functionalization for expanding DNA-encoded library (DEL) chemical space.
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Zhang et al. (2026) studied this question.
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