What does this research mean for the field?

The 1H-BIRDS-RESEGAW magnetic resonance imaging technique provides a feasible and quantitatively reliable method for mapping extracellular pH at submillimeter resolution in liver tumors. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the feasibility and quantitative accuracy of high-resolution extracellular pH imaging in a mouse liver tumor model using 1H-BIRDS with RESEGAW.

August 22, 2026NMR in BiomedicineOpen Access

High‐Resolution Imaging of Extracellular pH in Mouse Liver Tumor

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Authors

JSJessica Gois SantanaYale University SKSara KurdiYale University LPLisa Marie Helene PeschkeYale University

Discussion

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Implication

Preclinical study demonstrates reliable high-resolution extracellular pH mapping in mouse liver tumors, highlighting a viable method to evaluate tumor acidosis and therapy response.

Key Points

To evaluate the feasibility and quantitative accuracy of high-resolution extracellular pH imaging in a mouse liver tumor model using 1H-BIRDS with RESEGAW.
Imaged eight tumor-bearing C57BL/6J mice (Hepa1–6 model) on a 9.4 T scanner using 1H-BIRDS with RESEGAW and the agent TmDOTP5− at 0.6 mm isotropic resolution.
Validated results against 31P-MRSI with 3-APP and evaluated agreement via voxelwise Bland–Altman analysis after co-registration.
1H-BIRDS-RESEGAW demonstrated acidic tumor regions (pHe = 6.77 ± 0.14) relative to adjacent normal liver tissue (pHe = 7.14 ± 0.07).
Mean pHe measurements showed no significant difference compared to 31P-MRSI (tumor pHe = 6.81 ± 0.13; normal liver pHe = 7.14 ± 0.06), with a minimal mean bias of −0.005 pH units and variance under 0.1 pH units.

Cite This Study

Santana et al. (2026) studied this question.

synapsesocial.com/papers/6a895f87ca7ade938187e2fe https://doi.org/10.1002/nbm.70375

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August 22, 2026NMR in BiomedicineOpen Access

High‐Resolution Imaging of Extracellular pH in Mouse Liver Tumor

View Full Paper

Ask AI

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Authors

JSJessica Gois SantanaYale University SKSara KurdiYale University LPLisa Marie Helene PeschkeYale University

Discussion

Member takes

Implication

Preclinical study demonstrates reliable high-resolution extracellular pH mapping in mouse liver tumors, highlighting a viable method to evaluate tumor acidosis and therapy response.

Key Points

To evaluate the feasibility and quantitative accuracy of high-resolution extracellular pH imaging in a mouse liver tumor model using 1H-BIRDS with RESEGAW.
Imaged eight tumor-bearing C57BL/6J mice (Hepa1–6 model) on a 9.4 T scanner using 1H-BIRDS with RESEGAW and the agent TmDOTP5− at 0.6 mm isotropic resolution.
Validated results against 31P-MRSI with 3-APP and evaluated agreement via voxelwise Bland–Altman analysis after co-registration.
1H-BIRDS-RESEGAW demonstrated acidic tumor regions (pHe = 6.77 ± 0.14) relative to adjacent normal liver tissue (pHe = 7.14 ± 0.07).
Mean pHe measurements showed no significant difference compared to 31P-MRSI (tumor pHe = 6.81 ± 0.13; normal liver pHe = 7.14 ± 0.06), with a minimal mean bias of −0.005 pH units and variance under 0.1 pH units.

Cite This Study

Santana et al. (2026) studied this question.

synapsesocial.com/papers/6a895f87ca7ade938187e2fe https://doi.org/10.1002/nbm.70375

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