Why the study?
Does cholinergic modulation or GH pretreatment alter the GH response to GHRH in patients with IDDM compared to normal subjects?
Population
20 subjects, comprising 13 male subjects with insulin dependent diabetes mellitus and no clinical evidence…
Comparison
Pretreatment with pirenzepine 200 mg or… vs Control study with GHRH alone.
Design
RCT, random order
Authors
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Cholinergic enhancement and GH pretreatment fail to modulate GHRH-stimulated GH release in IDDM; confirms enhanced hypothalamic cholinergic tone with blunted autofeedback.
Does cholinergic modulation or GH pretreatment alter the GH response to GHRH in patients with IDDM compared to normal subjects?
Patients with IDDM exhibit abnormal neuroregulation of growth hormone, characterized by enhanced ambient hypothalamic cholinergic tone and reduced responsiveness to autofeedback.
Ismail et al. (1993) studied this question.
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