Key result
CT angiography demonstrated 96% agreement (95% CI 90-99%) with digital subtraction angiography for detecting ≥70% carotid stenosis, with 100% sensitivity and 100% negative predictive value.
Why the study?
Does CT angiography accurately evaluate carotid stenosis compared to digital subtraction angiography in patients with suspected stroke or TIA?
Population
Patients with interpretable CT angiography and digital subtraction angiography of the cervical carotid…
Comparison
CT angiography (CTA) of the head and neck vs Digital subtraction angiography using the North…
Design
Cohort, Two blinded readers for CTA and two blinded readers for DSA
Authors
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Supports CTA screening for severe carotid stenosis in stroke/TIA; leaves open prospective validation before replacing DSA.
Observational
Blinded readers
No
Does CT angiography accurately evaluate carotid stenosis compared to digital subtraction angiography in patients with suspected stroke or TIA?
CT angiography is a highly sensitive screening test with excellent negative predictive value for evaluating internal carotid artery stenosis in patients with suspected stroke or TIA.
Josephson et al. (2004) conducted an observational in Ischemic stroke or TIA. CT angiography (CTA) vs. Digital subtraction angiography (DSA) was evaluated on Agreement between CTA and DSA using a 70% cutoff value for stenosis (95% CI 90 to 99). CT angiography demonstrated 96% agreement (95% CI 90-99%) with digital subtraction angiography for detecting ≥70% carotid stenosis, with 100% sensitivity and 100% negative predictive value.
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