Population
Endothelin-converting enzyme from bovine endothelial cells
Comparison
Synthesized truncated analogues and… vs Full-length big ET-1, big ET-2, and big ET-3
Design
Preclinical
Authors
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Defines minimal ECE substrate motif; hypothesis-generating for selective inhibitors, does not yet inform clinical practice.
The specific carboxy-terminal sequence of big ET-1, particularly residues 27-34, is essential for its selective processing by endothelin-converting enzyme.
Okada et al. (1993) studied this question.
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