Key result
The copresence of NOS3 G894T and intron 4 VNTR risk-elevating genotypes increased the risk of ischemic stroke seven-fold (OR 7.083; 95% CI 0.866-57.963; p=0.029).
Why the study?
Do NOS3 genetic polymorphisms (G894T, T-786C, and intron 4 VNTR) increase the risk of ischemic stroke in the Turkish population?
Case-Control (n=390)
Do NOS3 genetic polymorphisms (G894T, T-786C, and intron 4 VNTR) increase the risk of ischemic stroke in the Turkish population?
Odds Ratio: 7.083 (95% CI 0.866–57.963)
p-value: p=0.029
While individual NOS3 variants showed no significant association, the combined presence of G894T and intron 4 VNTR polymorphisms significantly increases the risk of ischemic stroke in the Turkish population.
Combined NOS3 variants were associated with higher stroke risk; hypothesis-generating and should not yet change clinical testing or risk stratification.
In the present study, we aimed to investigate the relationship between endothelial nitric oxide synthase 3 (NOS3) G894T, T-786C, and intron 4 variable number of tandem repeat (VNTR) variants, alone or in combination, and the risk of incidence of ischemic stroke in the Turkish population. The genotypes for all polymorphisms were determined by polymerase chain reaction/restriction fragment length polymorphism techniques on 245 ischemic stroke patients and 145 controls. In the case-control analysis, no significant difference was observed between stroke patients and controls with respect to NOS3 G894T, T-786C, and intron 4 VNTR polymorphisms genotype and allele frequency distribution. However, the copresence of G894T and intron 4 VNTR risk-elevating genotypes in the same individual increased the risk of stroke seven times (odds ratio=7.083, 95% confidence interval=0.866-57.963, p=0.029).
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Özçelik et al. (2014) conducted a case-control in Ischemic stroke (n=390). Copresence of NOS3 G894T and intron 4 VNTR risk-elevating genotypes vs. Controls was evaluated on Incidence of ischemic stroke (OR 7.083, 95% CI 0.866-57.963, p=0.029). The copresence of NOS3 G894T and intron 4 VNTR risk-elevating genotypes increased the risk of ischemic stroke seven-fold (OR 7.083; 95% CI 0.866-57.963; p=0.029).
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