Population
Mice, rats, and human samples (in vitro and in vivo models)
Comparison
Intravenous injection of mouse angiotensin I… vs In vitro studies and cross-species comparisons
Design
Preclinical
Authors
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In vitro species differences in RAS components may not hold in vivo; leaves open questions on cross-species model validity for angiotensin research.
This preclinical study demonstrates significant species-specific differences in the renin-angiotensin system, specifically in converting enzyme and angiotensin I, between mice, rats, and humans.
Poulsen et al. (1970) studied this question.
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