Key result
Mouse angiotensinogen reacts exclusively with homologous mouse renin to release angiotensin, demonstrating a unique resistance to heterologous renin among non-primates.
Population
Mouse plasma and kidney extracts, plasma from nephrectomized mice, and renin or kidney extracts from other…
Comparison
Incubation of mouse plasma substrate with… vs Incubation with heterologous renin/kidney…
Design
Preclinical
Follow-up
3 weeks (for DCA and salt loading)
Authors
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Species specificity in mouse RAS cautions against heterologous models in research; leaves open evolutionary drivers of this exclusivity.
Mouse angiotensinogen exhibits unique species specificity, reacting exclusively with homologous renin to release angiotensin.
Oliver et al. (1966) studied this question. Homologous mouse renin vs. Heterologous renin (pig, rat, hamster, rabbit, man) was evaluated on Release of angiotensin. Mouse angiotensinogen reacts exclusively with homologous mouse renin to release angiotensin, demonstrating a unique resistance to heterologous renin among non-primates.
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