Why the study?
Does exogenous ATP improve the metabolic state in isolated nonperfused dog hearts?
Population
Isolated nonperfused dog hearts kept for 30 to 180 minutes at temperatures varying from 4 to 34°C
Comparison
Adenosine triphosphate solutions injected into… vs Control hearts not exposed to ATP
Design
Preclinical
Follow-up
30 to 180 minutes
Authors
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ATP may aid hypothermic cardiac preservation in animals; leaves open translation to human transplantation.
Does exogenous ATP improve the metabolic state in isolated nonperfused dog hearts?
Exogenous ATP improves the metabolic state of excised hypothermic dog hearts, suggesting a potential strategy for improving organ survival during preservation.
FEDELEŠOVÁ et al. (1969) studied this question.
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