Why the study?
Do chlordiazepoxide, secobarbital, amobarbital, or chlorothiazide alter the pharmacokinetics or pharmacodynamics of warfarin?
Population
8 subjects
Design
Other
Authors
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May warrant INR monitoring with barbiturates; Level 5 data leaves open need for prospective confirmation.
Do chlordiazepoxide, secobarbital, amobarbital, or chlorothiazide alter the pharmacokinetics or pharmacodynamics of warfarin?
Barbiturates (secobarbital and amobarbital) significantly reduce the anticoagulant effect of warfarin, whereas chlordiazepoxide and chlorothiazide can be used safely without altering its action.
Donald S. Robinson (1970) studied this question.
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