Why the study?
Do barbiturates interfere with the anticoagulant effect of coumarin drugs in patients treated for myocardial infarction?
Do barbiturates interfere with the anticoagulant effect of coumarin drugs in patients treated for myocardial infarction?
Barbiturates appear to interfere with the anticoagulant activity of coumarin drugs in humans, necessitating close monitoring of prothrombin times and dose adjustments.
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Barbiturates were associated with erratic warfarin control in post-MI patients; leaves open whether interaction warrants routine monitoring or dose adjustment without prospective data.
Mariah G. MacDonald (1968) studied this question.
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