Why the study?
Do barbiturates interfere with the anticoagulant effect of coumarin drugs in patients treated for myocardial infarction?
Population
52 patients admitted for myocardial infarction and treated with anticoagulants
Comparison
Barbiturates vs No barbiturates
Design
Cohort
Authors
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Barbiturates were associated with erratic warfarin control post-MI; hypothesis-generating and should not yet change monitoring practice.
Do barbiturates interfere with the anticoagulant effect of coumarin drugs in patients treated for myocardial infarction?
Barbiturates can interfere with the anticoagulant activity of coumarin drugs, leading to erratic control and requiring careful monitoring of prothrombin time.
Murdo G. MacDonald (1968) studied this question.
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