Key result
Administration of hypnotic drugs during bishydrocoumarin treatment increased the Quick index, while prothrombin + proconvertin activity, fibrinogen level, and platelet count were unaffected.
Why the study?
Does the co-administration of hypnotic drugs affect coagulation factors in patients treated with bishydrocoumarin?
Population
37 patients treated with bishydrocoumarin
Design
Case_series
Authors
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May warrant prothrombin time monitoring with hypnotic co-use in anticoagulated patients; leaves open clinical relevance and needs prospective confirmation.
Observational
Does the co-administration of hypnotic drugs affect coagulation factors in patients treated with bishydrocoumarin?
Hypnotic drugs can interact with oral anticoagulants to alter prothrombin time, and some patients exhibit true resistance to oral anticoagulants.
Stig‐Arne Johansson (1968) conducted an observational in Patients on oral anticoagulant therapy. Hypnotic drugs (Diminal duplex, Placidyl) was evaluated on Quick index, prothrombin + proconvertin activity, platelet count, and fibrinogen level. Administration of hypnotic drugs during bishydrocoumarin treatment increased the Quick index, while prothrombin + proconvertin activity, fibrinogen level, and platelet count were unaffected.
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