Why the study?
Do phenobarbital, glutethimide, and chloral betaine alter warfarin plasma levels and hypoprothrombinemic responses in male volunteers?
Population
10 male volunteers
Comparison
Phenobarbital, glutethimide, and chloral betaine… vs Placebo at bedtime for 3 week periods, followed…
Design
Other
Follow-up
3 weeks per treatment period
Authors
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Warrants INR monitoring with phenobarbital or glutethimide coadministration; leaves open generalizability beyond male volunteers.
Do phenobarbital, glutethimide, and chloral betaine alter warfarin plasma levels and hypoprothrombinemic responses in male volunteers?
Phenobarbital and glutethimide significantly reduce warfarin plasma levels and its hypoprothrombinemic effect, highlighting a clinically important drug interaction.
MacDonald et al. (1969) studied this question.
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