Why the study?
Does chloral hydrate alter prothrombin times or plasma warfarin levels in patients receiving long-term therapy with warfarin?
Population
17 subjects receiving long-term therapy with warfarin
Comparison
Chloral hydrate vs Placebo control treatment periods
Design
Other
Authors
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No need for warfarin adjustment with chloral hydrate; leaves open confirmation in larger, contemporary cohorts.
Does chloral hydrate alter prothrombin times or plasma warfarin levels in patients receiving long-term therapy with warfarin?
The clinical significance of any interaction between warfarin and chloral hydrate is negligible for patients on long-term warfarin therapy.
Paul F. Griner (1971) studied this question.
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