Why the study?
Does chloral hydrate potentiate the hypoprothrombinemic effect of warfarin in patients on chronic warfarin therapy?
Population
Patients receiving chronic warfarin therapy
Design
Other
Follow-up
1 week
Authors
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May warrant INR monitoring with concurrent use; leaves open confirmation in contemporary randomized cohorts.
Does chloral hydrate potentiate the hypoprothrombinemic effect of warfarin in patients on chronic warfarin therapy?
Chloral hydrate displaces warfarin from plasma albumin, significantly increasing its hypoprothrombinemic effect and necessitating a reduction in warfarin dosage to prevent bleeding.
Sellers et al. (1970) studied this question.
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