Why the study?
Does chloral hydrate interact clinically significantly with warfarin in patients on long-term warfarin therapy?
Population
14 volunteers undergoing initiation and maintenance of long-term warfarin therapy
Comparison
Chloral hydrate vs Placebo (during induction experiment)
Design
RCT, Administered alternately, Double-blind
Authors
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No clinically significant interaction during long-term warfarin use; confirms safe coadministration beyond induction-phase effects.
Does chloral hydrate interact clinically significantly with warfarin in patients on long-term warfarin therapy?
The pharmacological interaction between warfarin and chloral hydrate does not result in clinically significant changes in anticoagulant control during long-term therapy.
John A. Udall (1974) studied this question.
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