Why the study?
Does heptabarbital pretreatment alter the pharmacokinetics and anticoagulant effect of warfarin in humans?
Population
Humans
Design
Other
Authors
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Supports mechanism-specific INR monitoring with barbiturates and warfarin; leaves open generalizability to other inducers or anticoagulants.
Does heptabarbital pretreatment alter the pharmacokinetics and anticoagulant effect of warfarin in humans?
Heptabarbital decreases the anticoagulant response to warfarin solely by inducing the warfarin-metabolizing enzyme system, without altering its distribution or pharmacodynamics.
Levy et al. (1970) studied this question.
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