Why the study?
Does glucagon potentiate the hypoprothrombinemic action of warfarin in hospitalized patients?
Population
24 hospitalized patients on warfarin therapy treated for myocardial contractile failure
Design
Cohort
Authors
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High-dose glucagon was associated with potentiated warfarin effect; leaves open clinical significance pending larger prospective studies.
Does glucagon potentiate the hypoprothrombinemic action of warfarin in hospitalized patients?
Glucagon administration in patients on warfarin therapy can markedly potentiate its hypoprothrombinemic effect, increasing the risk of excessive anticoagulation and bleeding.
Jan Koch‐Weser (1970) studied this question.
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