Population
Isolated, demembranated Unio gill cilia
Comparison
0.1 mM ATP and Mg++ vs 2 mM MgSO4
Design
Preclinical
Authors
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ATP-Mg++ effects on dynein bridging in animal cilia extend mechanistic models; leaves open translation to human ciliopathies or therapy.
The study demonstrates a functional coupling of Mg++-induced bridging of dynein arms and subsequent ATP binding/hydrolysis in cilia.
F. D. Warner (1978) studied this question.
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