A Meta-Analysis of MitraClip Combined with Medical Therapy vs. Medical Therapy Alone for Treatment of Mitral Regurgitation in Heart Failure Patients
Why the study?
Does percutaneous mitral valve repair with MitraClip combined with medical therapy reduce death from any cause in heart failure patients with functional mitral regurgitation compared to medical therapy alone?
Population
2,121 participants from 6 observational studies with >80% functional mitral regurgitation in heart failure…
Comparison
Percutaneous mitral valve repair with MitraClip… vs Conservative medical therapy alone
Design
Meta-analysis
Follow-up
median 400 days
Authors
Discussion
Loading...
Member takes
Implication
Supports MitraClip addition in HF with functional MR; confirms survival benefit in study-level meta-analysis.
Structured PICO
Does percutaneous mitral valve repair with MitraClip combined with medical therapy reduce death from any cause in heart failure patients with functional mitral regurgitation compared to medical therapy alone?
P
Population
2,121 participants from 6 observational studies with >80% functional mitral regurgitation (MR) in heart failure. Patient-level analysis included 344 patients.
I
Intervention
Percutaneous mitral valve repair with MitraClip combined with medical therapy
C
Comparator
Conservative medical therapy alone
O
Outcome
Death from any causehard clinical
In patients with functional mitral regurgitation, MitraClip combined with medical therapy is associated with a significant survival benefit and reduced cardiac readmissions compared to medical therapy alone.
Cite This Study
Giannini et al. (2018) studied this question.