Mechanisms and Treatment of Resistant Hypertension
Population
Patients with resistant hypertension
Design
Review
Authors
Discussion
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Member takes
Implication
Supports aldosterone-targeted therapy in resistant hypertension; leaves open optimal screening thresholds and long-term outcomes.
Structured PICO
P
Population
Patients with resistant hypertension (defined as blood pressure that remains uncontrolled in spite of the use of ≥3 antihypertensive medications)
I
Intervention
Evaluation for secondary causes (including screening with plasma aldosterone/renin ratio) and addition of spironolactone to standard treatment
Hyperaldosteronism is a primary driver of resistant hypertension, and screening with a plasma aldosterone/renin ratio followed by targeted treatment with spironolactone is an effective management strategy.
Cite This Study
Pimenta et al. (2008) studied this question.