Key result
Fetal growth restriction is strongly linked to higher rates of adult hypertension.
Why the study?
The fetal origins of hypertension and its relationship to early growth patterns were not fully elucidated.
Does retarded growth in fetal life increase the risk of high blood pressure in adult life?
Cohort (n=25,000)
Does retarded growth in fetal life increase the risk of high blood pressure in adult life?
Answers are grounded in this paper and cite their sources.
This study demonstrates that hypertension in adulthood is programmed by an adverse environment in utero and impaired fetal development.
AIM: To elucidate the fetal origins of hypertension. METHODS: A systematic search was made for records of early growth, comprising measurements taken either at birth and/or during infancy, for groups of men and women now in middle-late life. Over 25,000 men and women born before 1931 were successfully traced. RESULTS: Retarded growth in fetal life was strongly related to high blood pressure in adult life. CONCLUSION: Hypertension is programmed by an adverse environment in utero. It is linked to impaired development in both early and late gestation.
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David J.P. Barker (1992) conducted a cohort in Hypertension (n=25,000). Retarded growth in fetal life vs. Normal fetal growth was evaluated on High blood pressure in adult life. Retarded growth in fetal life was strongly related to the development of high blood pressure in middle-late adult life among over 25,000 individuals.
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