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April 17, 2014Pharmacogenetics and Genomics

Rs495828 polymorphism of the ABO gene is a predictor of enalapril-induced cough in Chinese patients with essential hypertension

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Why the study?

Does the rs495828 polymorphism of the ABO gene predict enalapril-induced cough in Chinese patients with essential hypertension?

Population

450 Chinese patients with essential hypertension treated with 10 mg of enalapril maleate

Comparison

ABO genetic polymorphisms vs Non-carriers of the specific ABO genetic…

Design

Case-control

Authors

JLJian‐Quan LuoCentral South UniversityFHFazhong HeHohai UniversityZLZhiying LuoCentral South University

Discussion

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Implication

Supports rs495828 as candidate marker for enalapril cough; leaves open prospective validation before clinical use.

Structured PICO

Does the rs495828 polymorphism of the ABO gene predict enalapril-induced cough in Chinese patients with essential hypertension?

P
Population
450 Chinese patients with essential hypertension treated with 10 mg of enalapril maleate
I
Intervention
ABO genetic polymorphisms (specifically rs495828 TT genotype)
C
Comparator
Non-carriers of the specific ABO genetic polymorphisms
O
Outcome
Enalapril-induced cough (recorded when patients were bothered by cough and respiratory symptoms during enalapril treatment without an identifiable cause)safety

The rs495828 polymorphism of the ABO gene is associated with an increased risk of enalapril-induced cough in Chinese patients with essential hypertension, suggesting its potential as a pharmacogenomic marker.

Cite This Study

Luo et al. (2014) studied this question.

synapsesocial.com/papers/6a8a481720b5dc5751ec661dhttps://doi.org/10.1097/fpc.0000000000000050

Topics

Hypertension management
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