July 1, 1994Acta Physiologica Scandinavica

Graded action potentials generated by differentiated human neuroblastoma cells

View Full Paper

Ask AI

Bookmark

Population

Human SH-SY5Y neuroblastoma cells induced to differentiate by retinoic acid

Design

Preclinical

Authors

SJStaffan JohanssonUmeå University

Discussion

Member takes

Implication

Requires cardiac myocyte validation before clinical translation; leaves open whether Na+ current density modulates impulse variability in vivo.

Structured PICO

Population

Human SH-SY5Y neuroblastoma cells induced to differentiate by retinoic acid

Intervention

Rectangular current steps (tight-seal recording techniques)

Outcome

Stimulus-dependent impulses and resting membrane parameters (resting potential, input resistance, capacitance, time constant, Na+ and K+ currents)surrogate

In differentiated human SH-SY5Y neuroblastoma cells, the degree of impulse variability is correlated to the maximum Na+ current density.

Cite This Study

Staffan Johansson (1994) studied this question.

synapsesocial.com/papers/6a8a535b6099c68714334f36 https://doi.org/10.1111/j.1748-1716.1994.tb09752.x

View Full Paper

Ask AI

Bookmark

Implication

Requires cardiac myocyte validation before clinical translation; leaves open whether Na+ current density modulates impulse variability in vivo.

Graded action potentials generated by differentiated human neuroblastoma cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Graded action potentials generated by differentiated human neuroblastoma cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider