Population
In vitro pulsatile flow model testing three bileaflet aortic valves
Design
Preclinical
Authors
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May prompt valve design refinements to limit platelet damage; leaves open in vivo thrombosis thresholds for clinical translation.
In vitro testing of bileaflet aortic valves reveals that turbulence characteristics, specifically Reynolds shear stresses, can directly damage platelets and increase the risk of thrombosis.
Liu et al. (1999) studied this question.
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