What question did this study set out to answer?

To synthesize recent discoveries regarding the biosynthesis, evolutionary conservation, and physiological roles of protein O-mannosylation, with a focus on nervous system development and associated human pathologies.

August 11, 2023GlycobiologyOpen Access

Protein O-mannosylation: one sugar, several pathways, many functions

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Authors

MKMelissa KoffTexas A&M University PMPedro Monagas-ValentinTexas A&M University System BNBoris NovikovTexas A&M University

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Implication

Narrative review uncovers the biosynthesis and neural functions of protein O-mannosylation across animal models, highlighting its critical role in preventing congenital muscular dystrophies.

Key Points

To synthesize recent discoveries regarding the biosynthesis, evolutionary conservation, and physiological roles of protein O-mannosylation, with a focus on nervous system development and associated human pathologies.
Reviewed molecular and cellular literature characterizing protein O-mannosylation pathways and related congenital disorders from yeast to humans.
Analyzed genetic and mechanistic insights gained from the Drosophila model system to elucidate evolutionary conservation and in vivo functions.
Protein O-mannosylation is essential for nervous system structure and function, with biosynthetic defects driving severe neurological deficits and congenital muscular dystrophies.
Studies in Drosophila reveal conserved enzymatic pathways and identify key molecular targets required for tissue homeostasis and neuromuscular integrity.

Cite This Study

Koff et al. (2023) studied this question.

synapsesocial.com/papers/6a8a6358b11dee029fbd67e2 https://doi.org/10.1093/glycob/cwad067

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Implication

Narrative review uncovers the biosynthesis and neural functions of protein O-mannosylation across animal models, highlighting its critical role in preventing congenital muscular dystrophies.

Protein O-mannosylation: one sugar, several pathways, many functions

Discussion

Member takes

Implication

Key Points

Cite This Study

Protein O-mannosylation: one sugar, several pathways, many functions

Discussion

Member takes

Implication

Key Points

Cite This Study

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