August 1, 1999Molecular and Cellular BiologyOpen Access

Differentiation-Induced Internal Translation of c- sis mRNA: Analysis of the cis Elements and Their Differentiation-Linked Binding to the hnRNP C Protein

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Population

Nondifferentiated and differentiated cells (in vitro model)

Comparison

Analysis of the c-sis 5' UTR… vs Nondifferentiated vs differentiated cells

Design

Preclinical

Authors

OSOsnat Sella-TavorTel Aviv University GGGabi GerlitzAriel University SLShu‐Yun LeNanchang University

Discussion

Member takes

Implication

Does not support clinical translation yet; leaves open hnRNP C targeting in human vascular differentiation.

Structured PICO

Population

Nondifferentiated and differentiated cells (in vitro model)

Intervention

Analysis of the c-sis 5' UTR differentiation-activated internal ribosomal entry site (D-IRES) and hnRNP C protein binding

Comparator

Nondifferentiated vs differentiated cells

Outcome

Translational modulating activity and hnRNP C binding to the D-IRESsurrogate

The c-sis 5' UTR acts as a translational modulator in response to cellular differentiation, mediated by the binding of hnRNP C to a specific differentiation-sensing region.

Cite This Study

Sella-Tavor et al. (1999) studied this question.

synapsesocial.com/papers/6a8a716c336687a3262e58d8 https://doi.org/10.1128/mcb.19.8.5429

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Differentiation-Induced Internal Translation of c- sis mRNA: Analysis of the cis Elements and Their Differentiation-Linked Binding to the hnRNP C Protein

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Differentiation-Induced Internal Translation of c- sis mRNA: Analysis of the cis Elements and Their Differentiation-Linked Binding to the hnRNP C Protein

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider