In situ hybridization for quantitative assay of infectious hepatitis A virus
Population
Cells infected with hepatitis A virus (HAV)
Comparison
In situ hybridization using single-stranded RNA… vs RNA probes identical to HAV genomic RNA…
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Advances quantitative HAV detection in animal models; leaves open clinical diagnostic validation.
Structured PICO
P
Population
Cells infected with hepatitis A virus (HAV)
I
Intervention
In situ hybridization using single-stranded RNA probes complementary to HAV genomic RNA
C
Comparator
RNA probes identical to HAV genomic RNA; preimmune serum
O
Outcome
Quantitative enumeration of hepatitis A virus (foci of infected cells)surrogate
A newly developed in situ hybridization technique using single-stranded RNA probes allows for rapid and quantitative enumeration of infectious hepatitis A virus.
Cite This Study
Xi et al. (1989) studied this question.