June 1, 1990Antiviral chemistry & chemotherapyOpen Access

Flavonoids: Potent Inhibitors of Poliovirus RNA Synthesis

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Population

Poliovirus-infected HeLa cells

Comparison

Flavonoids (3-methyl quercetin and Ro-090179) vs Hydroxybenzyl-benzimidazole (HBB) and guanidine

Design

Preclinical

Authors

MGMaría Eugenia GonzálezUniversidade de São Paulo FMFrancisco Martínez‐AbarcaEstación Experimental del Zaidín LCLuis CarrascoThe Honourable Society of Lincoln's Inn

Discussion

Member takes

Implication

Ro-090179 offers a potent in vitro probe for poliovirus RNA replication; leaves open therapeutic translation pending in vivo studies.

Structured PICO

Population

Poliovirus-infected HeLa cells

Intervention

Flavonoids (3-methyl quercetin and Ro-090179)

Comparator

Hydroxybenzyl-benzimidazole (HBB) and guanidine

Outcome

Inhibition of poliovirus replication and viral RNA synthesissurrogate

Ro-090179 is a highly potent and selective inhibitor of poliovirus plus-stranded RNA synthesis, making it a valuable tool for studying viral RNA replication.

Cite This Study

González et al. (1990) studied this question.

synapsesocial.com/papers/6a8a7d4e439f8b7e0143520f https://doi.org/10.1177/095632029000100304

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