February 1, 1996Cardiovascular Research

Ventricular relaxation in the stage 24 chick embryo following changes in volume and blockade of Na+ and Ca2+ channels

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Why the study?

Does blockade of Na+ or Ca2+ channels alter ventricular relaxation in stage 24 chick embryos?

Population

Hamilton-Hamburger stage 24 chick embryos

Comparison

Intravenous injection of lidocaine or verapamil vs Baseline measurements and intravenous injection…

Design

Preclinical

Follow-up

60 seconds post-injection

Authors

ZNZahra J. NaheedJohn H. Stroger, Jr. Hospital of Cook County ALA. Lahoti SHSharon F HughesNorthwestern University

Discussion

Member takes

Implication

Blockade of Na+ channels with lidocaine slows ventricular relaxation in the embryonic chick heart, suggesting a role for the Na+-Ca2+ exchange system in early cardiac development.

Structured PICO

Does blockade of Na+ or Ca2+ channels alter ventricular relaxation in stage 24 chick embryos?

Population

Hamilton-Hamburger stage 24 chick embryos (n=17 total; 4 for isovolumic relaxation time derivation, 13 for ventricular pressure recording)

Intervention

Intravenous injection of lidocaine (n=4) or verapamil (n=4)

Comparator

Baseline measurements and intravenous injection of chick Ringer's solution (n=5)

Outcome

Ventricular relaxation characterized by a monoexponential model (tau [isovolumic relaxation constant] and P infinity) at 30 s and 60 s post-injectionsurrogate

Blockade of Na+ channels with lidocaine slows ventricular relaxation in the embryonic chick heart, suggesting a role for the Na+-Ca2+ exchange system in early cardiac development.

Cite This Study

Naheed et al. (1996) studied this question.

synapsesocial.com/papers/6a8a915b176d2ac34cfbe8b1 https://doi.org/10.1016/s0008-6363(95)00210-3

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Implication

Blockade of Na+ channels with lidocaine slows ventricular relaxation in the embryonic chick heart, suggesting a role for the Na+-Ca2+ exchange system in early cardiac development.

Ventricular relaxation in the stage 24 chick embryo following changes in volume and blockade of Na+ and Ca2+ channels

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Ventricular relaxation in the stage 24 chick embryo following changes in volume and blockade of Na+ and Ca2+ channels

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider