Key result
Verapamil cuts ventricular pressure ~27% in chick embryos, reducing blood flow and ventricular weight.
Why the study?
The effect of chronic verapamil treatment on growth and function of the embryonic ventricle was studied to understand myocardial mass adjustment to workload.
Does verapamil alter ventricular function and growth in chick embryos?
Population
Stage 18 chick embryos
Comparison
Verapamil treatment vs saline-treated control and untreated embryos
Design
Experimental study with miniosmotic pump delivery
Follow-up
Up to stage 29
Authors
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Verapamil reduces embryonic ventricular growth via load reduction; leaves open relevance to human fetal cardiac development.
Does verapamil alter ventricular function and growth in chick embryos?
Absolute Event Rate: 1.59% vs 2.17%
p-value: p=<0.05
Chronic verapamil treatment in chick embryos reduces ventricular pressure, blood flow, and ventricular weight, indicating that calcium channel blockade alters embryonic cardiac function and growth.
Clark et al. (1991) studied Chick embryos. Verapamil vs. Saline-treated control and untreated embryos was evaluated on Ventricular pressure at stage 27 (p=<0.05). Verapamil treatment in chick embryos significantly decreased ventricular pressure (1.59 vs 2.17 mmHg, P<0.05), dorsal aortic blood flow, ventricular weight, and DNA compared with saline controls.
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