January 1, 1998IEEE Transactions on Biomedical Engineering

A model analysis of aftereffects of high-intensity DC stimulation on action potential of ventricular muscle

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Population

Beeler-Reuter's action potential model of ventricular muscle

Design

Preclinical

Authors

ISIchiro SakumaBunkyo University THTadashi HaraguchiUtsunomiya University KOKatsuhiro OhuchiJuntendo University

Discussion

Member takes

Implication

Supports membrane rupture hypothesis for DC shock arrhythmogenesis; leaves open translation to clinical defibrillation safety.

Structured PICO

Population

Beeler-Reuter's action potential model of ventricular muscle

Intervention

Simulated high-intensity DC stimulation via incorporation of a leak conductance (Gpore, maximal value 40 to 80 microS/cm2) with exponential decay (tau pore 5-50 s)

Outcome

Action potential changes including prolonged depolarization, diastolic depolarization, and spontaneous excitationsurrogate

Computational modeling supports the hypothesis that strong DC shocks (> 15 V/cm) produce arrhythmogenic responses in ventricular muscle through transient sarcolemmal membrane rupture.

Cite This Study

Sakuma et al. (1998) studied this question.

synapsesocial.com/papers/6a8aae351e528df4f2ec79b3 https://doi.org/10.1109/10.661274

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A model analysis of aftereffects of high-intensity DC stimulation on action potential of ventricular muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A model analysis of aftereffects of high-intensity DC stimulation on action potential of ventricular muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider