Key result
Genetic studies in humans and mice reveal that lipid transfer proteins and HDL recycling play critical roles in HDL catabolism and the determination of plasma HDL levels.
Population
Humans and mice (including wild-type and ob/ob mice models)
Design
Review
Authors
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Raises caution for CETP inhibition despite HDL elevation; leaves open clinical translation of HDL catabolism mechanisms.
This lecture summarizes the complex mechanisms of HDL metabolism and reverse cholesterol transport, highlighting that increased HDL via CETP deficiency may paradoxically increase CAD risk.
Tall et al. (2000) conducted a review in Atherogenesis and HDL metabolism. Lipid transfer proteins and HDL recycling was evaluated. Genetic studies in humans and mice reveal that lipid transfer proteins and HDL recycling play critical roles in HDL catabolism and the determination of plasma HDL levels.
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