Key result
CRT interruption episodes were associated with lower median resynchronization rates compared to no episodes (98.5% vs 100%, P=0.044), primarily due to inappropriate inhibition of LV pacing.
Why the study?
Problems associated with the left ventricular lead and sensing can lead to loss of biventricular stimulation and CRT nonresponse, but are challenging to detect and have an unclear incidence.
Observational (n=61)
Yes
Absolute Event Rate: 98.5% vs 100%
p-value: p=0.044
Inadequate programming, specifically active LV sensing with T-wave protection, is the main cause of impaired resynchronization in CRT devices with LV sensing.
No takes yet. Share an insight, caveat, or question.
CRT interruptions may compromise resynchronization; leaves open optimal strategies to minimize LV pacing inhibition.
Haeberlin et al. (2020) conducted an observational in Cardiac resynchronization therapy (CRT) (n=61). CRT interruption episodes vs. No CRT interruption episodes was evaluated on Resynchronization rates (p=0.044). CRT interruption episodes were associated with lower median resynchronization rates compared to no episodes (98.5% vs 100%, P=0.044), primarily due to inappropriate inhibition of LV pacing.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: