March 1, 1999Catheterization and Cardiovascular Interventions
Simultaneous intracoronary ultrasound and Doppler flow studies distinguish flow-mediated from receptor-mediated endothelial responses
Key result
Simultaneous IVUS and Doppler flow measurements after intracoronary adenosine showed peak flow at 18+/-2 sec and maximal lumen area at 43+/-11 sec (P<0.001), distinguishing flow-mediated responses.
Why the study?
Can simultaneous IVUS and Doppler flow studies distinguish flow-mediated from receptor-mediated endothelial responses in patients after heart transplantation?
Population
35 patients undergoing routine annual cardiac catheterization after heart transplantation
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Distinguishes flow- from receptor-mediated endothelial responses post-transplant; leaves open whether this refines risk assessment or therapy.
Study Design
Type
Observational (n=35)
Structured PICO
Can simultaneous IVUS and Doppler flow studies distinguish flow-mediated from receptor-mediated endothelial responses in patients after heart transplantation?
P
Population
35 patients undergoing routine annual cardiac catheterization after heart transplantation.
I
Intervention
Simultaneous intravascular ultrasound (IVUS) and Doppler flow measurements during intracoronary administration of adenosine, acetylcholine, and nitroglycerin
O
Outcome
Changes in epicardial lumen area and coronary blood flowsurrogate
Main Result
p-value: p=<0.001
Simultaneous IVUS and Doppler flow measurements can distinguish between agonist-mediated and flow-mediated endothelial responses, providing insights into coronary endothelial function.
Cite This Study
Hollenberg et al. (1999) conducted an observational in Heart transplantation (n=35). Intracoronary administration of adenosine, acetylcholine, and nitroglycerin was evaluated on Time to peak flow versus time to maximal lumen area (p=<0.001). Simultaneous IVUS and Doppler flow measurements after intracoronary adenosine showed peak flow at 18+/-2 sec and maximal lumen area at 43+/-11 sec (P<0.001), distinguishing flow-mediated responses.